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KMID : 0903220010020020107
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Journal of the Korean Cleft Palate-Craniofacial Association
2001 Volume.2 No. 2 p.107 ~ p.110
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A Study on the Morphologic Change of the Tongue Muscle in Down Syndrome Children
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Park Yong-Sam
Yang Won-Yong
Ko Bub-Min
Yang Moon-Ho
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Abstract
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Anatomy of oral cavity in Down syndrome is characterized by hypotonic macroglossia, small oral cavity, narrow palate with high-arch shape and hypertrophy of tonsil and adenoid. Because of such a anatomic characteristics, they show difficulty in respiration, mastication, swallowing and articulation. So far we operated on 135 children with Down syndrome for partial glossectomy in average volume of 4.6cc. This study is histopathologic finding of partially resected tongue in 4 cases, analyzed by histochemical stain and electron microscopy. The results of histochemical study showed predominant of Type 2 myofiber and interstitial edema, fibrosis and chronic nonspecific inflammation. In the study of electron microscope, the size and number of mitochondria were increased, but structural abnormality was not showed.
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KEYWORD
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Down syndrome, Tongue muscle biopsy
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